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Exploradio Origins sparks ideas and conversation with its unique and engaging 90 second nutshell approach. Each episode highlights the work of one of the more than 200 fellows at the Institute for the Science of Origins at Case Western Reserve University.

Exploradio Origins: Tracing the Origins of High-Altitude Adaptation

Cynthia Beall from Case Western Reserve University researched the genetics of hemoglobin levels in Tibetans.

"For a long time, all the work on how people adapt to high altitude involved Europeans going to high altitude," said Cynthia Beall, a professor of anthropology at Case Western Reserve University.

"In the 70s, anthropologists started asking 'does everyone in the world adapt in the same way?' Early work showed, no, they don’t."

Cynthia Beall is a professor of anthropology at Case Western Reserve University.

Beall found that, while natives of the Andes mountains have elevated levels of hemoglobin - the oxygen-carrying molecule - natives of the Tibetan Himalayas don’t. They adapt by increasing their blood-flow. 

Beall then found that a lower level of hemoglobin actually correlated with a higher number of successful pregnancies in Tibetans. She wondered if the answer was genetic.

It turns out that Tibetans have a unique version of a gene called EPAS1 that correlates with their low hemoglobin levels, and they’ve traced that gene to an ancient source: "...a fossil population that we only know from a couple of fossil teeth, and their DNA," Beall said. 

"Yes, we can trace the origin of this important feature of Tibetan biology nowadays back 50,000 years to the Denisovans in Siberia."

Exploradio Origins is a weekly feature produced in conjunction with the Institute for the Science of Origins at Case Western Reserve University. Tune in to 89.7 WKSU every Thursday afternoon during All Things Considered to listen to Exploradio Origins. You can find each segment posted online after it airs. Explore all the segments here.

Kellen McGee is currently pursuing a PhD in nuclear and accelerator physics at the National Superconducting Cyclotron Laboratory at Michigan State University. She graduated from Johns Hopkins University in 2014. She’s held a number of research positions, ultimately becoming a research assistant in a biophysics and structural biology lab at Case Western Reserve University. There, the Institute for the Science of Origins instantly became her intellectual home. Central to the ISO’s mission is science communication.