News
News Home
Quick Bites
Exploradio
News Archive
News Channel
Special Features
NPR
nowplaying
On AirNewsClassical
Loading...
  
School Closings
WKSU Support
Funding for WKSU is made possible in part through support from the following businesses and organizations.

Greater Akron Chamber

Akron Children's Hospital

The Holden Arboretum


For more information on how your company or organization can support WKSU, download the WKSU Media Kit.

(WKSU Media Kit PDF icon )


Donate Your Vehicle to WKSU

Programs Schedule Make A Pledge Member BenefitsFAQ/HelpContact Us
Health and Medicine


Cleveland study explains how 'good' cholesterol turns bad
Inflammation in the arteries causes the oxidation of HDL, which then contributes to plaque formation instead of reducing it
by WKSU's JEFF ST. CLAIR


Reporter / Host
Jeff St. Clair
 
Dr. Stanley Hazen is director of the Center for Cardiovascular Diagnostics & Prevention at the Cleveland Clinic. His latest study details how inflammation causes 'good' HDL to change into a form that contributes to heart disease.
Courtesy of Jeff St.Clair
Download (WKSU Only)
In The Region:

Researchers at the Cleveland Clinic have found that not all supposedly ‘good’ cholesterol is really good. Their study released Sunday also explains why simply raising your levels of good cholesterol doesn’t lead to better heart health.

WKSU’s Jeff St.Clair reports that the findings may change the testing and treatment of heart disease.

LISTEN: Inflammation and dysfunctional HDL

Other options:
Windows Media / MP3 Download (1:08)


For years we’ve been told that HDL or high density lipoprotein is the good type of cholesterol and LDL or low density lipoprotein is the ‘bad’ cholesterol.

But researchers at the Cleveland Clinic have discovered that not all HDL is good. And their findings help explain why drugs designed to raise levels of HDL don’t prevent heart disease.

Stanley Hazen led the study.  He says inflammation in the arteries changes the HDL from good to bad. Products of an inflammatory enzyme, myeloperoxidase, are now shown to selectively target the main protein in HDL.

“And it turns it into not a protective form but a harmful or dysfunctional form.”

And that dysfunctional HDL, instead of removing cholesterol from the arteries, adds to its buildup. Hazen says the discovery adds further proof that heart disease is linked to inflammation.

“It’s like trying to separate the grease from a grease fire, you need the oil and grease to keep the fire going but there’s something that has to be providing the heat. The heat itself is the inflammation, the cholesterol and the lipid is the fuel, and that’s why there so intertwined.”

Hazen and his team are developing tests to identify ‘bad’ HDL, and new therapies to prevent its formation.

The five year study looked at more than 600 patients at the Cleveland Clinic. The results appear in the latest edition of Nature Medicine. 

Add Your Comment
Name:

Location:

E-mail: (not published, only used to contact you about your comment)


Comments:




 
Page Options

Print this page

E-Mail this page / Send mp3

Share on Facebook




Stories with Recent Comments

Bridgestone exec indictments are latest step in a billion-dollar price-fixing case
Why is O.P.E.C Not investigated and charges brought against it and it's member companies? It sounds exactly the same...

Ohio's new drilling rules rely on known earthquake faults
requiring drillers to place seismic monitors when they drill within 3 miles of known fault lines. This comment really upsets me!! What good does an instrument t...

Kasich's gubernatorial ad focuses on his blue-collar roots
John Kasich is the biggest con-man in America. He will say one thing and then do the opposite. He is terribly successful at fooling the public and he is worki...

Cab drivers who refuse to drive Gay Games taxis will be replaced
the irony is that most americans distrust or hate muslims much more than they hate gays!! silly ignorant bigots-GO HOME!!!

New transportation companies come to Cleveland
Ride-sharing companies are breaking laws and regulations every day. From regulatory fee evasion to use of smartphone while driving (and even two smartphones(!) ...

Cleveland anti-poverty agency executive resigns amid financial probe
That committee won't be too independent. He plans to stay on until after the new appointee is chosen.

How can you wipe a criminal record clean?
Great article! NO CLINIC in May 2014, however, because it's graduation month for students For the next dates of the FREE Legal Clinic to help with Expungment,...

Drilling remains suspended while ODNR investigates NE Ohio earthquakes
Flaring and lights, so has all been halted? Also, smell of HS2 and sounds of an auger/drilling/water rushing underground. So, has all been halted? In light of t...

Will the Ohio River carry fracking wastewater?
Texas $ vs. WV citizens . Who will our governor listen to?

Copyright © 2014 WKSU Public Radio, All Rights Reserved.

 
In Partnership With:

NPR PRI Kent State University

listen in windows media format listen in realplayer format Car Talk Hosts: Tom & Ray Magliozzi Fresh Air Host: Terry Gross A Service of Kent State University 89.7 WKSU | NPR.Classical.Other smart stuff. NPR Senior Correspondent: Noah Adams Living on Earth Host: Steve Curwood 89.7 WKSU | NPR.Classical.Other smart stuff. A Service of Kent State University