News
News Home
Quick Bites
Exploradio
News Archive
News Channel
Special Features
NPR
nowplaying
On AirNewsClassical
Loading...
  
School Closings
WKSU Support
Funding for WKSU is made possible in part through support from the following businesses and organizations.

Hospice of the Western Reserve

Cedar Point

Area Agency on Aging 10B, Inc.


For more information on how your company or organization can support WKSU, download the WKSU Media Kit.

(WKSU Media Kit PDF icon )


Donate Your Vehicle to WKSU

Programs Schedule Make A Pledge Member BenefitsFAQ/HelpContact Us
Health and Medicine


Change in FDA policy fast tracks testing of Alzheimer's drug
But other scientists are unable to reproduce dramatic improvements shown in preliminary tests in Cleveland
by WKSU's JEFF ST. CLAIR


Reporter / Host
Jeff St. Clair
 
Dr. Gary Landeth (right) hopes to prove that Bexarotene can treat Alzheimer’s disease through phase 1 clinical trials. He and then graduate student Paige Cramer started a company called Rexceptor to develop the drug for clinical use.
Courtesy of Jeff St.Clair
Download (WKSU Only)
In The Region:

A promising new treatment for Alzheimer’s disease developed in Cleveland has run into some roadblocks, but backers of a repurposed drug are moving forward with clinical trials.

LISTEN: ST.CLAIR ON ALZHEIMER'S DRUG

Other options:
Windows Media / MP3 Download (1:04)


The drug Bexarotene was originally used to treat skin cancer. But Gary Landreth, a neuroscientist at Case Western Reserve University, showed last year that mice bred to have Alzheimer’s disease dramatically improved when given the drug. Now Landreth is ready to test it on people.

He says a recent change in FDA policy allows the drug to be tested on healthy people to determine whether it reduces soluble amyloid beta proteins that are believed to lead to Alzheimer’s.

“The FDA has recognized we now need to treat people who are at risk of Alzheimer’s disease but are cognitively normal, and that changes everything,” Landreth says.

The scientific community, however, is not convinced the drug actually works. Last week, the journal "Science" published independent studies that failed to reproduce Landreth’s dramatic results. However, he says he is still holding out hope his original findings in mice will be validated.

“Proving this mechanism in humans is essential to any subsequent development of the drug,” Landreth says.

Landreth says he could know by the end of the year whether Bexarotene will move on to further testing or join the dozens of other would-be Alzheimer treatments littering the path to a cure.

Listener Comments:

Does anyone have any idea as to what dosage they will be testing?


Posted by: DICKY_DOOO on May 28, 2013 4:05AM
Add Your Comment
Name:

Location:

E-mail: (not published, only used to contact you about your comment)


Comments:




 
Page Options

Print this page

E-Mail this page / Send mp3

Share on Facebook




Stories with Recent Comments

Crystal Ball says Ohio governor's race is done
How much is the Kasich campaign paying you to keep repeating the phrase "woman who is not his wife"? Fitzgerald was in the car with a friend who happens to be f...

Plane that crashed killing Case students is a popular training aircraft
The following is incorrect. The last few words should read "UNDER maximum gross take-off weight." “They have a normal take-off speed and all those take-off...

Exploradio: The never-ending war against superbugs
Super Federico ,we are so proud of you ,and very lucky to be among your friends . Keep it up human kind needs people like you to survive .Thanks for being so d...

Ohio's Lyme disease-carrying tick population is exploding
Interesting report. The last sentence needs some editing. It isn't a good idea to "save garments carrying ticks for analysis." The garments carrying t...

Teach for America enters third year in Ohio
For more background on TFA, check out http://reconsideringtfa.wordpress.com/

Faith leaders hold week-long prayer vigil at Ohio Statehouse
I think this is the wrong link to the audio. Its Andy Chow about cigarette taxes.

A $30 million plan to turn Cleveland's Public Square from gray to green
The current plan is for the Land Bank, RTA, and Mr. Jeremy Paris to run a bus line through the new Public Square and cutting the park in half. Save Public Squar...

Medina County residents question safety of proposed natural gas pipeline
I'm very concerned about this nexus project. I've received mail requesting my permission to allow the company to survey my property. I don't understand how thi...

A small group of tea party and Democrats protest at Kasich campaign stop
Enjoyed your excellent coverage of the statehouse for sometime now, never dreamed I'd be on. The feedback from people has been great. Thank you. Doris Adams

Top staffers are leaving the FitzGerald gubernatorial campaign
I's too bad that the dirt on Fitzgerald dug up by Kasich's operatives and publicized heavily by the Yellow Plain Dealer has caused the weak staffers of the Fitz...

Copyright © 2014 WKSU Public Radio, All Rights Reserved.

 
In Partnership With:

NPR PRI Kent State University

listen in windows media format listen in realplayer format Car Talk Hosts: Tom & Ray Magliozzi Fresh Air Host: Terry Gross A Service of Kent State University 89.7 WKSU | NPR.Classical.Other smart stuff. NPR Senior Correspondent: Noah Adams Living on Earth Host: Steve Curwood 89.7 WKSU | NPR.Classical.Other smart stuff. A Service of Kent State University