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Health and Medicine

Promising new treatment for Alzheimer's
An anti-cancer drug reverses Alzheimer's in mice, researchers are hoping it will have the same effect in people

Reporter / Host
Jeff St. Clair
In The Region:

Researchers at Case Western Reserve University have found that a drug already used to treat skin cancer may also treat Alzheimer’s disease.

The research published this month in the journal “Science” shows dramatic improvement in the brain function of lab-mice with the disease.  

Paige Cramer is lead author of the study.  She says the results are promising, but cautions there is no guarantee the treatment will work in humans.

“We have to remember this is a mouse model, and unfortunately the number of times that researchers in the world have cured this disease in the mouse obviously far exceeds the number of times that we’ve brought a product to market for human consumption.”


Paige Cramer, CWRU researcher

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The drug, bexarotene is the first to show rapid reduction of Amyloid proteins in the brain.  The build-up of Amyloid plaque is believed to be a cause of Alzheimer’s in humans. 

Cramer says clinical trials will begin in the next few months.  

Listener Comments:

Please let me know how my mother can be part of the trials. She has Alzheimers, is in perfect health otherwise with perfect labs. THis is a cruel disease as you know. Thank you for your efforts. Ph 702 497 8417

Posted by: Susan Woods (Albuquerque, NM) on April 9, 2012 10:04AM
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